Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation targeting an underground arms cache in Syrian territory employed by the IS group, per a report from the UK Ministry of Defence.
The facility, located using intelligence, was assessed as containing munitions and bombs, the announcement noted, and was positioned in mountains just north of the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a number of entry passages down to the facility... early reports are that the target was engaged successfully," the MoD said.
There was no sign of any harm to civilians in the strike conducted Saturday night and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - enforced militant control over large swathes of Iraq and Syria until 2019.
"This strike underscores the UK's leading role, and determination to operate in unison with our partners, to stamp out any resurgence of Daesh and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary said.
UK warplanes have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of the group after its military defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank the personnel of British forces participating in this mission for their expertise and their valour," the Defence Secretary said. "They were among a great many UK service members deployed over the holidays. This operation, to remove dangerous terrorists who endanger our security, demonstrates how our armed forces are always on standby, continuously, keeping Britain secure at home and powerful internationally."
In December, the US military conducted what it described as a "massive strike" against IS targets in Syria, following an assault killed two US servicemembers and a local interpreter in the Palmyra area.
The United Nations estimates IS still maintains an estimated 5,000 to 7,000 militants in both countries.